The streets of Cairo have been alight with anti-US protests. There are fears the clashes could spread further on Friday the day of prayer throughout Muslim countries.
The US embassy in Egypt's capital was the latest to be targeted. Over 220 people were reported injured. Police fended off attempts by stone-throwing protesters to breach the perimeter of the US embassy while fighting broke out in streets beyond the embassy.
Politicians were emphatic in distancing themselves from the film produced in the USA which ridicules Islam and sparked the outbreak of protests.
"To us, to me personally, this video is disgusting and reprehensible. The U.S. government had absolutely nothing to do with this video. We absolutely reject its content and message. America's commitment to religious tolerance goes back to the very beginning of our nation," stressed U.S. Secretary of State Hillary Clinton.
Four people were reportedly killed and dozens injured in clashes between police and Yemeni security forces in Sana'a.
Libyan authorities have said they have made four arrests as a result of their investigation into the attack which killed US ambassador Christopher Stevens and three other Americans in related violence in Benghazi earlier this week